Chemical found in hard plastics, currency bills and thermal paper receipts may increase the potential of aggressiveness of breast cancer, a new study has found.
Bisphenol S (BPS), a substitute for the chemical Bisphenol A (BPA) used in the plastic industry, shows the potential for increasing the risk of breast cancer through its behaviour as an endocrine-disrupting chemical, researchers said.
Researchers from Oakland University in the US studied the effects of BPS on estrogen receptor-alpha and the BRCA1 gene.
Most breast cancers are estrogen receptor positive and according to the US National Cancer Institute, 55 to 65% of women who inherit a harmful mutation in the BRCA1 gene will develop breast cancer.
“Despite hopes for a safer alternative to BPA, studies have shown BPS to exhibit similar estrogen-mimicking behaviour to BPA,” said the study’s principal investigator Sumi Dinda.
Their study confirmed that BPS acts like estrogen in breast cancer cells, Dinda said, adding, “So far, BPS seems to be a potent endocrine disruptor.”
Although further study of BPS in breast cancer cells is needed for confirmation, he suggested that “if a woman has a mutated BRAC1 gene and uses products containing BPS, her risk for developing breast cancer may increase further.”
The results, which tested BPS in human breast cancer cells, is scheduled to be presented at ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando, Florida.